Formulas. Prices. Evidence.

The publication / Sources

SHOW THE RECORD.

What we read, what it establishes and where its usefulness stops.

November 11 article updates

These four articles contain dated source notes for their latest revision. Earlier register entries below remain a historical record of what was checked at the stated time.

Earlier source register

Offer details in these earlier notes may have changed. For the four revised articles, consult the update notes linked above.

Every record carries its own retrieval date. Product and purchase terms sit alongside regulatory guidance and clinical context; historical research keeps its publication date. Public marketing is not an independently verified outcome.

Provider record

CoreAge Rx — Time Out ↗

Current strengths, $48/month starting offer, expanded ingredient descriptions and hormone/application cautions. Dedicated visit CTA /go/timeout confirmed from current PDP; provider-source links retain PDP. No individual order, prescription or exact-mixture clinical trial verified.

Checked 2026-09-27

Wisp — Estriol Face Cream ↗

Rendered offer and expanded age-policy FAQ checked. Exact patient-specific formula remains for confirmation; company ratings are not product trial results.

Checked 2026-09-26

Alloy — M4 Eye Cream Rx ↗

Offer accessed September 26, 2026: 1% estriol plus peptides, $90 for one advertised three-month bottle supply. Product title is Eye Cream despite the URL. Provider claims are not independent outcomes; bottle volume and full base were not confirmed.

Checked 2026-09-27

QuickMD — Estriol face cream ↗

$59 thirty-day medication supply and separate $79 visit; prescription not guaranteed. Exact strength, full base, live scheduling and final checkout unverified; absorption and safety claims attributed.

Checked 2026-09-27

Musely — The Aging Repair Cream ↗

Current $36/month with two-month auto-refill display, 17,123 self-report cohort and conditional 60-day refund language. No completed checkout, one-time total or controlled exact-product study established.

Checked 2026-09-27

Musely — Aging Repair ingredient and use guide ↗

Names Plump estriol 0.3% and hyaluronic acid 0.5%, with individualized-prescription caveat. Routine wording mixes morning and night references; review defers to written prescriber directions.

Checked 2026-09-27

CoreAge Rx — Time Out sales landing page ↗

Current destination of /go/timeout. Lists twelve-month $576, six-month $330, three-month $189 and one-month $75 totals; some displayed monthly rates differ by cents from total/division arithmetic. No auto-billing and refund if not approved are advertised, not checkout-verified. Testimonials, comparative claims and timelines are not independent trial evidence.

Checked 2026-09-27

Likeness Rx — Estrogen Face Cream ↗

Official product ingredients, displayed prices and subscription renewal, checked October 4, 2026. No patient care or fulfillment test performed.

Checked 2026-10-04

Regulatory record

FDA — Is it a cosmetic, a drug, or both? ↗

Intended-use distinctions and the absence of a legal cosmeceutical category. Used for classification principles, not stale regulatory implementation deadlines or a ruling on a particular retail product.

Checked 2026-09-26

DailyMed — estradiol vaginal cream 0.01%, Mylan ↗

Specific vaginal estradiol label with ANDA marketing category and systemic-absorption language. It does not establish facial estriol efficacy, comparable exposure or instructions for repurposing either product.

Checked 2026-09-26

FDA — Reporting serious problems to FDA ↗

Official voluntary consumer reporting information for medical-product adverse events, quality problems and related concerns. Reports support surveillance; they do not establish causation, deliver medical care or settle refunds.

Checked 2026-09-26

Clinical context

MedlinePlus — Tretinoin topical ↗

Drug information revised December 15, 2025. Used for retinoid identity and broad precautions, not a dosing schedule for a compounded combination.

Checked 2026-09-26

ACOG — Compounded Bioidentical Menopausal Hormone Therapy (2023) ↗

November 2023 consensus discusses limited evidence for adjunct testing to prescribe or dose compounded menopausal hormone therapy. Broad MHT guidance is not a validated facial estriol testing algorithm; some clinical circumstances warrant separate testing decisions.

Checked 2026-09-26

AAD — Taking pictures of your skin ↗

July 20, 2023 guidance on useful photographs and clinic-approved secure sharing. It does not establish hormone eligibility from an image or verify any provider’s upload process.

Checked 2026-09-26

Research record

M4 Estriol Eye Cream clinical report RE241054.V02 (July 15, 2025) ↗

Alloy-sponsored monadic report: 40 enrolled, 34 completed, no comparator described, 12-week outcomes and baseline/week-eight estriol sampling. Pages 14 and 18 and the laboratory appendix were checked directly: probable bilateral eye burning was recorded; laboratory uncertainty limits absorption interpretations. Small selected population and short follow-up cannot establish universal or long-term safety.

Checked 2026-09-26

Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo. ↗

Primary full article: methods, main results, participant table, figure captions, discussion and funding reviewed on publisher site

Checked 2026-10-21

Clinical public guidance

National Eye Institute — Dry eye ↗

Updated August 6, 2025. Symptoms, assessment and treatment categories; not evidence for facial estriol or a personal eye-drop regimen.

Checked 2026-09-27

Manufacturer device document

Regulatory guidance

Regulatory

FDA — Understanding drug recalls ↗

Lot matching, risk categories and notice-specific action; not every recall has a public announcement. General guidance is not a patient-specific continuation decision.

Checked 2026-09-27

FDA — Drug recalls ↗

Official announcement index and recall explanation. No complete recall-history audit or claim that any listed estriol product is currently recalled.

Checked 2026-09-27

Provider shipping reference and supplied service information

Official product or purchase terms

FAQs – FEM+ ↗

Public source checked for this editorial review; no product-use or transaction test.

Checked 2026-10-14

Returns Policy ↗

Public source checked for this editorial review; no product-use or transaction test.

Checked 2026-10-14